Prof. Dr. med. Dr. sc. nat.

Alexander Navarini

Quantitative dermatology at the intersection of clinical medicine, immunology, genomics and image recognition.

Chair of Dermatology & Allergology, University Hospital Basel Clinical Professor of Dermatology, University of Basel
Portrait of Alexander Navarini
Chair · Dermatology & Allergology
University Hospital Basel
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Clinical dermatologist, venereologist and scientist

Born in Basel, raised in Graubünden and Aargau. Medical studies in Basel and Paris, MD-PhD training as an experimental immunologist in Zurich, and a research fellowship in modern genomics at King’s College London.

Since November 2018, Chair of Dermatology and Allergology at University Hospital Basel and clinical professor of dermatology at the University of Basel. His approach combines clinical observation with measurable data — from genomics as much as from imaging.

Languages: German · English · French · Italian · Kiswahili.

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Clinical scope

In 2025 the Department of Dermatology and Allergology at USB recorded around 82,700 outpatient contacts — from general dermatology to highly specialised care.

Core areas

  • General dermatology
  • Psoriasis and eczema
  • Acne and hidradenitis suppurativa
  • Dermato-oncology and skin-cancer screening
  • Dermatologic surgery and emergency dermatology

Further fields

  • Tropical dermatology
  • Cutaneous infectiology
  • Hair, STI and proctology
  • Genodermatosis clinic
  • Laser dermatology (FMCH I–V)
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Navarini Lab — genotype meets phenotype

The Navarini Lab connects two worlds of data. Exome-wide sequencing uncovers disease-driving genetic variants that are then followed up functionally — with a focus on neutrophil-mediated and autoinflammatory skin diseases. Work on generalised pustular psoriasis and the IL-36 axis (including IL36RN and AP1S3 variants) has shaped today’s disease classification and contributed to targeted therapies such as spesolimab.

In parallel, the team develops machine-learning methods for dermatology: self-supervised learning, data-quality and bias audits, anomaly detection and foundation models — alongside work on global fairness and diversity, for example using image data from Sub-Saharan Africa.

At the Department of Biomedicine the group runs a keratinocyte organoid platform and an AI group for quantitative skin analysis. The aim is a robust genotype–phenotype correlation as a basis for future clinical decision support.

Interested in collaborating? The lab is open to partnerships and accepts referrals for the genodermatosis clinic.

Track I — Genome

Sequence → Function → Therapy

Next-generation sequencing, functional validation and targeted therapies for autoinflammatory and immune-mediated skin diseases.

Track II — Image

Image → Feature → Prediction

Dermoscopy and machine learning for objective, robust and fair image analysis — from data quality to foundation models.

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Scientific contributions

350+
Publications in total
17,500+
Citations (Google Scholar)
66
h-index
221
i10-index

Including contributions at computer-science venues (NeurIPS, MICCAI, CVPR and others). Full list on Google Scholar and PubMed.

Selected publications — clinic & genetics

2026Clinical phenotypes of 504 patients with pustular psoriasis from Europe and EgyptClinical and Experimental Dermatology
2025IL-36-driven pustulosis: transcriptomic signatures match between generalized pustular psoriasis and AGEPJournal of Allergy and Clinical Immunology
2025Mimicking Darier disease in vitro: a human epidermal organoid approachExperimental Dermatology
2021Trial of spesolimab for generalized pustular psoriasisNew England Journal of Medicine
2017European consensus statement on phenotypes of pustular psoriasisJEADV
2014AP1S3 mutations are associated with pustular psoriasis and impaired Toll-like receptor 3 traffickingAmerican Journal of Human Genetics
2014The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasisNature Communications
2012RORγt+ innate lymphocytes and γδ T cells initiate psoriasiform plaque formation in miceJournal of Clinical Investigation
2005Toll-like receptor engagement converts T-cell autoreactivity into overt autoimmune diseaseNature Medicine

Selected publications — AI & image analysis

2025Planet-wide performance of a skin disease AI algorithm validated in Koreanpj Digital Medicine
2025Is hyperbolic space all you need for medical anomaly detection?MICCAI
2025Robust T-Loss for medical image segmentationMedical Image Analysis
2024Intrinsic self-supervision for data quality auditsNeurIPS
2024PASSION for dermatology: bridging the diversity gap with pigmented skin images from Sub-Saharan AfricaMICCAI
2024Towards scalable foundation models for digital dermatologyPreprint / ML4H
2023Towards reliable dermatology evaluation benchmarksML4H @ NeurIPS
2023SANO: score-based diffusion model for anomaly localization in dermatologyCVPR Workshops
2022Deep-learning-based fast OCT image denoising for smart laser osteotomyIEEE Transactions on Medical Imaging
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Academic roles and committees

Roles beyond the immediate clinical and research work.

Role · USB

Chief Physicians’ Spokesperson

Elected spokesperson of the chief physicians’ conference at University Hospital Basel.

Role · Unibas

Faculty Committee

Member of the Faculty Committee of the University of Basel.

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Contact

University Hospital Basel

Department of Dermatology and Allergology

Burgfelderstrasse 101

4055 Basel, Switzerland

Get in touch

Secretariat and appointment requests via USB.

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